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What is Osteo-arthritis?
Osteo-arthritis (OA) is most common form of arthritis affecting mostly the Knees.

How common is Osteo-arthritis?
Osteo-arthritis is most affecting one out of eight people between the ages of 18 and 79. According to Arthritis Foundation, approximately 16 million Americans suffer from Osteo-arthritis, three times as many women as men. Osteo-arthritis has increased recently due to sedentary lifestyle as people walking less, are more over-weight, eat fast food, junk food etc and are not keeping the muscles toned by doing quality exercises. so they are bound to suffer from knee disorders which is simply gravity and weight leading to wearing-out of cartilages. Also more Osteo-arthritis is seen due to increase in awareness and life expectancy, and increase in treatment modalities.

At what age does osteo-arthritis occur?
Most common age for osteo-arthritis is after 60-65 years and this is a normal course of events like losing hair or getting grey hair. But when it occurs in the late 40's or early 50's, then this is due to bad lifestyle.
How does Osteo-arthritis occurs?
Cartilage contains fluid and elastic tissue, and functions to reduce friction as the joint moves. It acts as a shock absorber and as the sliding surface that covers the ends of bones. Osteo-arthritis results from chemical changes in the cartilage that cause it to break down faster than it can be produced.

Knee starts degenerating with age which is more when there is extra weight, diabetes. gout, autoimmune diseases, etc. Gradually the smooth and shiny cartilage between the two bones of the thigh and leg starts wearing out and the bone strikes bone and this leads to a lot of pain and stiffness, especially early in the morning. There is stiffness in the morning and patient requires to take a few steps before he can walk properly.

Previous infection of the joint may predispose to Osteo-arthritis by altering the chemical makeup of cartilage. The weakened cartilage causes it to wears out due to which bone rubs against bone. ultimately leadings to Osteo-arthritis and increased bone density, which may result in bones that are less able to absorb impacts and to protect cartilage from trauma.
What treatment are available for O.A.?
Till now there was no known cure for Osteo-arthritis. The treatments available were:
Decrease the pain with medicines, Herbs and Heat or cold applications
Supportive measures like Weight loss, Rest, Nutrition / food supplements
Assistive devices to make life easier.
Exercise and Paraffin bath etc
Surgical treatments for severe Osteo-arthritis with significant loss of cartilage. These include :
Arthroscopy for pain relief or to fix the joint
Osteotomy to correct joint deformity
Arthrodesis to immobilize joint by fixing bones
Joint replacement for severe joint deterioration

Surgery for Osteo-arthritis is usually considered a choice surgery unless patient is unfit for surgery. However it may need several months of rehabilitation after surgery and an artificial joint may only last for 10 to 20 years when it may wears out and need repeat surgery.

 

New non-surgical Osteo-arthritis treatment
Now knee joint cartilage can be regenerated and repaired by QMR based Tissue Engineering with Cytotron Therapy. QMR regenerates degenerated cartilage and relieves chronic pain and disability of Knee non-invasively with multi-frequency rotating quantum electromagnetic resonating beams. Many knees can be saved from knee replacement surgery.

What is the mechanism of Quantum Magnetic Resonance (QMR) Tissue Engineering (Regeneration and Degeneration)?
QMR produces high power multi frequency rotating quantum electromagnetic resonating beams that can be 'focussed ' on the site required to be treated.

What is the Principle of QMR in Tissue Regeneration and Degeneration?

Rotational Field Quantum Magnetic Resonance (RFQMR) technology utilized highly complex quantum electromagnetic beams in the sub-radio and near-radio frequency spectrum. The beams are precisely controlled and focused onto tissues to alter the proton spin inside and outside the cells therein generating streaming voltage potentials. This alters cell membrane potential and "Jams" the "Command and Control" of the target tissue cells stimulating cartilage growth.

How does QMR work in Tissue Regeneration of the cartilage?
Like other tissues, bone and cartilage are constantly being built up and broken down by a variety of metabolic and physical influences. The major stimulus for bone and cartilage formation is a signal generated when these structures are subjected to tension or compression. This explains why bone atrophies in the absence of any significant pressure, such as weightlessness during space travel or immobilization in a cast. The transmission of this signal is also impaired following joint injury due to trauma or diseases such as Osteo-arthritis.

In other words, when you take a step, putting weight on the joint, the cartilage is compressed, the fluid gets displaced, and it carries with it mobile ions, the sodium ions, leaving behind the negatively charged proteoglycan carboxyl and sulfate ions. This generates an electric potential because you have "neutralized" negative charges. This is called a streaming potential.
QMR is designed to characterize and reproduce the required signal that initiates these regenerative activities even though they are at rest). by the induction of a spin in the hydrogen atoms thus creating a streaming potential in the extra cellular matrix (ECM) when bone or cartilage are placed under a load.

What are the results of the treated?
As reported in the Journal of the Indian Society of Aerospace Medicine by Wg Cdr VG Vasishta, Dr RV Kumar, and Surg Cdr LJ Pinto evaluation of Osteo-arthritis patients treated with QMR. Using the Knee Society Scoring System and dynamometry. there was a highly significant improvement in Pain Score, Total Knee Score, Total Functional Score, Range of Movement and force of extension and the improvement persisted after the treatment.

Almost all patients show subjective improvements and are out of all pain killers by the 4th exposure. Results are seen three months post treatment. By the end of the treatment, almost all of the patients can walk for 1 to 5 km, without pain. About 40% can squat down on the floor, which they could not do it earlier. Upon 30 days follow up 95% patients are almost normalized, can climb stairs without help
Objectively, radiological evidence shows visible changes, and graphical measurement reveled 1 to 3.5 mm growth in cartilage during 30 days follow-up.
Dynamometry showed that, the joint capacity had gone up from as less as 5 kg before exposure to 45 kg during 30 days follow-up.
Range of Motion, Extension Lag, Flexion Contracture, Joint Stability and Alignment were all very significantly improved when evaluated using knee society scoring.
These patients do not need knee replacement surgery any more.

Is the treatment painful?
No, the treatment is absolutely painless. Patients can even listen to music, see television or read during the treatment.

How is QMR therapy evaluated and what are the expected results?

Almost all patients show improvements
Most patients have no pain by 4th exposure.
Almost all patients can walk for 1 to 5 km,
40% can squat down on the floor
Upon 30 days follow up 95% patients are almost normalized, can climb stairs
X-rays / MRI shows 1 to 3.5 mm growth in cartilage during 30 days follow-up.
Dynamometry shows increased joint capacity from less than 5 kg before exposure to 45 kg during 30 days follow-up.
Range of Motion, Extension, Flexion, Joint Stability and Alignment improve significantly when evaluated using knee society scoring.

 

The affected joint (knee) is placed inside QMR machine.
The desired exposure characteristics (like the cartilage to bone gap, skin to cartilage distance, Name, age, gender, height and weight etc.,) are fed into the computer. The computer then computes various wave front and spin frequencies, pulse amplitudes, field strength etc.,
There after the operator precisely focuses the beams on the required site. The treatment is given usually for 30 minutes daily for a period of 21 days.
The patients are evaluated by x-rays, Ultra-sound scans, etc in the beginning of the treatment, after 21 days and once again after 90 says, to understand the sustained effect. The Subjects do not feel any pain or discomfort during the treatment, all parameters are periodically measured on the body surface.

 

Comparison

Arthroscopy

Replacement

QMR

Procedure

Endoscopic treatment

Surgical prosthesis replacement

Purely external with beam of rays

Anaesthesia

Sometimes

Yes

Nil

Blood transfusion

No

May be

No

Scar of cut

Minor

Yes

No

Pain

Yes

Yes

No

Hospital stay

Few hours

Few days

½ hour daily

Return to work

In days

In days to weeks

Same day

Danger of procedure

+

++

Negligible

Anaesthesia unfit Patients

Possible

Not possible

Possible

Major complications

+

++

Negligible

Procedure deaths

Very Rare

Rare

Nil

Complications

+

++

Not known

Preventive effect

No

No

Yes

Tissue Regeneration

No

No

Often

Acceptance by patients

Reluctant due to risk & expenses

Reluctant due to risk & expenses

Very well accepted.

Acceptance by doctors

Accepted well

Accepted well

Reluctant - new & awareness lacking


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